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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Focal Adhesion Kinase (FAK)-TAS-301
TAS-301

Chemical Structure : TAS-301

CAS No.: 193620-69-8

TAS-301 (TAS301)

货号: PC-45578Not For Human Use, Lab Use Only.

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits PDGF-induced tyrosine phosphorylation of both FAK and paxillin.

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10 mg ¥880 In stock
25 mg ¥1280 In stock
50 mg ¥1980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits PDGF-induced tyrosine phosphorylation of both FAK and paxillin.
TAS-301 also inhibits PDGF-induced elevation of [Ca2+]i and activation of CaMK II, reduces the extent of F-actin stress fiber depolymerization observed in response to PDGF at 10 uM.

物理化学性质&存储条件

分子量 357.4019
分子式 C23H19NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 38 mg/mL

Chemical Name/SMILES

2H-Indol-2-one, 3-[bis(4-methoxyphenyl)methylene]-1,3-dihydro-

参考文献

1. Sasaki E, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1043-50.

2. Muranaka Y, et al. J Pharmacol Exp Ther. 1998 Jun;285(3):1280-6.

3. Sasaki E, et al. Pharmacology. 2001 Jul;63(1):17-27.

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