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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Focal Adhesion Kinase (FAK)-GSK2256098
GSK2256098

Chemical Structure : GSK2256098

CAS No.: 1224887-10-8

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GSK2256098 (GTPL-7939, GSK-2256098, GTPL7939)

货号: PC-42177Not For Human Use, Lab Use Only.

GSK2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM.

规格 价格 库存 数量
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM.
GSK2256098 (GTPL-7939) dispalys high selectivity over a panel of 261 kinases, including the nearest FAK family member, Pyk2 (>1,000-fold).
GSK2256098 (GTPL-7939) inhibits FAK activity through targeting the phosphorylation site of FAK Y397.
GSK2256098 (GTPL-7939) decreases levels of phosphorylated Akt and ERK, cell viability, anchorage-independent growth, and motility in L3.6P1 cells.
GSK2256098 (GTPL-7939) causes lower microvessel density, less cellular proliferation, and higher apoptosis rates in the Ishikawa model.

物理化学性质&存储条件

分子量 414.8886
分子式 C20H23ClN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 30 mg/mL
Chemical Name/SMILES

Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-

参考文献

1. Zhang J, et al. Cell Cycle. 2014;13(19):3143-9.

2. Soria JC, et al. Ann Oncol. 2016 Dec;27(12):2268-2274.

3. Thanapprapasr D, et al. Mol Cancer Ther. 2015 Jun;14(6):1466-1475.

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