Conteltinib |CAS:1384860-29-0 Probechem Biochemicals

Chemical Structure : Conteltinib

CAS No.: 1384860-29-0

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Conteltinib (CT-707, CT707)

货号: PC-61370Not For Human Use, Lab Use Only.

CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.

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10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo.
CT-707 (Conteltinib) effectively inhibits the activation of FAK induced by cabozantinib.
CT-707 (Conteltinib) displays potent activities in arresting cancer cell growth, promoting cell detachment, and decreasing wound healing, also exhibits potent anticancer activities in vivo, inhibits tumor growth and metastasis in T47D, Karpas299, and 4T1 xenograft models.

物理化学性质&存储条件

分子量	635.832
分子式	C32H45N9O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[(2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-N-(propan-2-yl)benzene-1-sulfonamide

参考文献

1. Patent WO/2012/092880A1.

2. Wang DD, et al. Mol Cancer Ther. 2016 Dec;15(12):2916-2925.

3. Cui C, et al. J Pharm Biomed Anal. 2018 Jan 31;153:1-8.

Conteltinib (CT-707, CT707)

生物&药学活性

物理化学性质&存储条件

参考文献

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Conteltinib (CT-707, CT707)

生物&药学活性

物理化学性质&存储条件

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