| Cat. No. |
Product Name |
Information |
| PC-28142 |
Isoprenaline
Beta-adrenoceptor agonist
|
Isoprenaline (isoproterenol) is a non-selective beta-adrenergic receptor agonist, stimulates both β1- and β2-adrenergic receptors, produces vasodilation, can also stimulate tachyarrhythmias. |
| PC-28027 |
KMCA-0011
α2C adrenoceptor
|
KMCA-0011 is a high potent α2C Adrenoceptor (α2C AR) antagonist with Ki of 56.7 nM, shows antidepressant activity and alleviates depressive behaviors by enhancing BDNF and synaptic plasticity. |
| PC-28010 |
Photoazolol-2
β2AR blocker
|
Photoazolol-2 is a photoswitchable β2-adrenergic receptor (β2AR) blocker (β-blocker) with IC50 of 106.6 nM (Cis-photoazolol-2), demonstrating higher antagonism upon illumination. |
| PC-28009 |
Photoazolol-1
β2AR blocker
|
Photoazolol-1 is a photoswitchable β2-adrenergic receptor (β2AR) blocker (β-blocker) with pEC50 of 7.73 (Dark, trans-photoazolol-1), 52-fold selective over under light condition (cis-photoazolol-1, pEC50=6.01). |
| PC-27918 |
AP-7-168
β2AR NAM
|
AP-7-168 is a specific β-arrestin-biased negative allosteric modulator (NAM) of β2-adrenergic receptor (β2AR), mediates β2AR dimerization with pEC50 of 5.93 in HEK cells, is >1,000-fold effective at inhibiting β-arrestin2 recruitment versus cAMP production. |
| PC-25680 |
β1AR antagonist Compound 11
β1AR modulator
|
β1AR antagonist Compound 11 (β1AR PAM antagonist C11) is a selective, allosteric modulator of β1-adrenergic receptor (β1AR) and PAM antagonist, selectively potentiates the binding affinity of orthosteric agonists to the β1AR while potently inhibiting downstream signaling following β1AR activation. |
| PC-25232 |
ADRIANA
α2B adrenoceptor antagonist
|
ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor. |
| PC-24799 |
ATR-258
β2AR agonist
|
ATR-258 (Compound 15) is a specific GRK-biased β2 adrenergic receptor (β2AR) agonist with pEC50 of 6.87, increases glucose uptake with low cAMP generation. |
| PC-24569 |
Dabuzalgron
α1A-AR agonist
|
Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist with pKi of 7.39 for the displacement of [3H]-prazosin binding to CHO-K1 membranes. |
| PC-24568 |
CCF219B
α1A-AR PAM
|
CCF219B (Compound 3, Cmpd-3) is a potent, selective positive allosteric modulator of the α1A-adrenergic receptor (α1A-AR) with an affinity of 30 nM, 10-50-fold selectivity against the α1B- and α1D-AR subtypes. |
| PC-22600 |
WB4101
α1A adrenoceptor antagonist
|
WB4101 is a potent, α1A-adrenergic selective antagonist with pKB value of 8.9 in rabbit aorta. |
| PC-21196 |
Mirabegron
β3-adrenoceptor agonist
|
Mirabegron (YM178) is a potent, selective selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
