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首页-小分子抑制剂&激动剂-GPCR-Adrenergic Receptor-KMCA-0011
KMCA-0011

Chemical Structure : KMCA-0011

CAS No.: 3109524-36-6

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KMCA-0011 (KMCA0011)

货号: PC-28027Not For Human Use, Lab Use Only.

KMCA-0011 is a high potent α2C Adrenoceptor (α2C AR) antagonist with Ki of 56.7 nM, shows antidepressant activity and alleviates depressive behaviors by enhancing BDNF and synaptic plasticity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KMCA-0011 is a high potent α2C Adrenoceptor (α2C AR) antagonist with Ki of 56.7 nM, shows antidepressant activity and alleviates depressive behaviors by enhancing BDNF and synaptic plasticity.

物理化学性质&存储条件

分子量 397.90
分子式 C22H24ClN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(4-benzylpiperidin-1-yl)ethyl)-5-chlorobenzo[d]oxazole-2-carboxamide

参考文献

1. Kobeom Seo, et al. Bioorg Med Chem Lett. 2026 Feb 1:131:130467.

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