| Cat. No. |
Product Name |
Information |
| PC-43963 |
Ziprasidone
D2/5-HT2A antagonist
|
Ziprasidone (CP 88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-26505 |
Cyproheptadine
5-HT2A antagonist
|
Cyproheptadine hydrochloride is a potent and orally active 5-HT2A receptor antagonist and histamine H1 receptor (HRH1) inverse agonist, promotes FOXO3 nuclear translocation and increases FOXO target genes while suppressing inflammation. |
| PC-26483 |
AG-670
NNMT inhibitor, 5-HT3 NAM
|
AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. |
| PC-26338 |
Lumocaserin hydrochloride
5-HT2C agonist
|
Lumocaserin hydrochloride is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-26337 |
Lumocaserin
5-HT2C agonist
|
Lumocaserin is a potent, selective serotonin 2C receptor (5-HT2C receptor) agonist with EC50 of 11 nM (Emax=88%), with limited activity against 5-HT2B and 5-HT2A receptors. |
| PC-26210 |
GSK958108
5HT1A antagonist
|
GSK958108 (GSK-958108) is a potent, selective and orally bioavailable 5HT1A receptor antagonist. |
| PC-25986 |
DOI-NBOMe
5-HT2A agonist
|
DOI-NBOMe is a potent, selective and Gq-biased agonist of 5-HT2A receptor (5-HT2AR) with pEC50 of 8.01. |
| PC-25920 |
SB-216641A
5-HT1B antagonist
|
SB-216641A (SB-216641 hydrochloride) is a selective partial agonist/antagonist of 5-HT1B receptor, shows high affinity and selectivity for h5-HT1B receptors over h5-HT1D receptors, inhibits the function of SKF-99101H. |
| PC-25761 |
25C-NBF
5-HT2A agonist
|
25C-NBF is a potent, selective 5-HT2A agonist with binding Ki of 0.8 nM and calcium mobilization EC50 of 2.3 nM, displays 2625-, 180-, 59-fold selective over 5-HT1A, 5-HT2B and 5-HT2C receptors respectively, exhibits antidepressant effects. |
| PC-25735 |
S-Pindolol
5-HT1A/1B antagonist
|
S-Pindolol (l-Pindolol, (S)-(-)-Pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist, also is a partial β-adrenoceptor agonist. |
| PC-25734 |
Buspirone
5-HT1A agonist
|
Buspirone is an orally active 5-HT1A receptor agonist and dopamine D2 autoreceptorsant antagonist, shows anxiolytic effects. |
| PC-25709 |
Rizatriptan benzoate
5-HT1D agonist
|
Rizatriptan benzoate (MK-462, MK-0462) is a potent and selective 5-HT1D receptor agonist with binding pIC50 of 7.3, shows little to no affinity for 5-HT1A, 5-HT2C, 5-HT2A and 5-HT3 receptors. |
