Alosetron (GR-68755) | 5-HT3 antagonist | Probechem Biochemicals

Chemical Structure : Alosetron

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Alosetron (GR-68755X, GR-68755)

货号: PC-45944Not For Human Use, Lab Use Only.

Alosetron (GR-68755) is a potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.

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生物&药学活性

Alosetron (GR-68755) is a potent and selective 5-HT3 receptor antagonist has been shown to be beneficial in the treatment of irritable bowel syndrome.

Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 of ~55 nM.

Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.

物理化学性质&存储条件

分子量	294.351
分子式	C17H18N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-

参考文献

1. Audolfsson G, et al. Aliment Pharmacol Ther. 1999 May;13 Suppl 2:39-47.

2. Zhai J, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):374-82.

3. Saslow SB, et al. Gut. 1998 May;42(5):628-34.

Alosetron (GR-68755X, GR-68755)

生物&药学活性

物理化学性质&存储条件

参考文献

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Alosetron (GR-68755X, GR-68755)

生物&药学活性

物理化学性质&存储条件

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