| Cat. No. |
Product Name |
Information |
| PC-28229 |
(R)-α-methylhistamine
H3 receptor agonist
|
(R)-α-methylhistamine (RAMH, (R)-(-)-α-Methylhistamine) is a potent, selective and brain-penetrant agonist of H3 histamine receptor (H3R) with Kd of 50.3 nM, enhances memory retention and attenuates memory impairment in vivo. |
| PC-28213 |
Astemizole
H1 receptor antagonist, hERG blocker
|
Astemizole (R43512) is a second-generation histamine H1-receptor antagonist with IC50 of 4 nM, also shows potent hERG K+ channel blocking activity with IC50 of 0.9 nM. |
| PC-28212 |
Cisapride monohydrate
hERG blocker, 5-HT4 agonist
|
Cisapride monohydrate (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells. |
| PC-28211 |
Cisapride
hERG blocker, 5-HT4 agonist
|
Cisapride (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells. |
| PC-28210 |
Tiapride
Dopamine D2/D3 receptor antagonist
|
Tiapride is a potent, selective dopamine D2/D3 receptor antagonist with IC50 of 110-320 nM and 180 nM, respectively, shows antidyskinetic activity and anxiolytic activity. |
| PC-28209 |
Tiapride hydrochloride
Dopamine D2/D3 receptor antagonist
|
Tiapride hydrochloride is a potent, selective dopamine D2/D3 receptor antagonist with IC50 of 110-320 nM and 180 nM, respectively, shows antidyskinetic activity and anxiolytic activity. |
| PC-28206 |
AM1476 hydrochloride
5-HT2B inhibitor
|
AM1476 hydrochloride is a highly selective 5-HT2B receptor (5-HT2BR) inhibitor with IC50 of 5.8 nM, showed only low activity at the5-HT2AR (IC50 >10 000 nM) and 5-HT2CR. |
| PC-28049 |
25CN-NBOH hydrochloride
5-HT2A agonist
|
25CN-NBOH hydrochloride is a potent, highly selective and brain-penetrant 5-HT2A receptor agonist with Ki of 1.1 nM ([3H]ketanserin). |
| PC-27960 |
Flibanserin
5-HT1A agonist, 5-HT2A antagonist
|
Flibanserin (BIMT-17, BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with Ki of 1 nM and 49 nM, respectively, shows anti-depression and anti-anxiety effects. |
| PC-27286 |
Alverine citrate
5-HT1A antagonist
|
Alverine citrate is a synthetic derivative of papaverine and selective 5-HT1A receptor antagonist with IC50 of 101 nM, is an antispasmodic agent to alleviate smooth muscle spasms. |
| PC-27115 |
PRX-08066
5-HT2B antagonist
|
PRX-08066 is a potent, selective 5-HT2B receptor (5-HT2BR) antagonist with Ki of 3.4 nM, causes selective vasodilation of pulmonary arteries. |
| PC-27114 |
SB200646
5-HT2B/2C antagonist
|
SB200646 (SB-200646A) is a potent, selective and orally active 5-HT2B/2C receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively, shows electrophysiological and anxiolytic properties. |
