| Cat. No. |
Product Name |
Information |
| PC-49667 |
TDO2 inhibitor LM10
TDO inhibitor
|
LM10 is a relatively specific, competitive inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2) with Ki of 5.6 uM and IC50 of 0.62 uM (hTDO), does not inhibit IDO. |
| PC-49666 |
680C91
TDO inhibitor
|
680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) with Ki of 51 nM. |
| PC-49665 |
709W92
TDO inhibitor
|
709W92 is a small molecule inhibitor of both tryptophan 2,3-dioxygenase (TDO) and 5-hydroxytryptamine (5-HT) reuptake, shows antidepressant efficacy. |
| PC-49664 |
NTRC 3531-0
TDO inhibitor
|
NTRC 3531-0 is a brain-penetrable, selective inhibitor of L-tryptophan-catabolizing enzyme tryptophan 2,3-dioxygenase (TDO) with IC50 of 490 nM (hTDO) in biochemical assays and cellular IC50 of 816 nM in HEK-hTDO. |
| PC-49662 |
LPM3480226
IDO1/TDO dual inhibitor
|
LPM3480226 (LY-01013) is a potent, selective IDO1/TDO dual inhibitor, inhibits the initial and rate-limiting enzymes in tryptophan metabolism, which play an essential role in mediating immunosuppression in tumor microenvironment. |
| PC-49660 |
PVZB3001
IDO1/TDO dual inhibitor
|
PVZB3001 (PVZB 3001) is a selective and cell-permeable dual inhibitor of IDO1 and TDO with IC50 value of 0.62 μM for rhTDO and 1.71 μM for rhIDO1, respectively. |
| PC-49658 |
TDO inhibitor BNTD
TDO inhibitor
|
BNTD is a highly potent, selective tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50 of 30 nM, > 21-fold selectivity over IDO. |
| PC-23418 |
TDO2 inhibitor Cpd-2
TDO2 inhibitor
|
TDO2 inhibitor Cpd-2 is a potent, selective small molecule inhibitor of the apo form of human TDO2 with IC50 of 14.8 nM in human TDO2 cellular assay utilizing SW48 cells. |
| PC-23417 |
TDO2 inhibitor Cpd-1
TDO2 inhibitor
|
TDO2 inhibitor Cpd-1 is a potent, selective small molecule inhibitor of the apo form of human TDO2 with IC50 of 327 nM in human TDO2 cellular assay utilizing SW48 cells. |
