709W92

Chemical Structure : 709W92

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货号: PC-49665Not For Human Use, Lab Use Only.

709W92 is a small molecule inhibitor of both tryptophan 2,3-dioxygenase (TDO) and 5-hydroxytryptamine (5-HT) reuptake, shows antidepressant efficacy.

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生物&药学活性

709W92 is a small molecule inhibitor of both tryptophan 2,3-dioxygenase (TDO) and 5-hydroxytryptamine (5-HT) reuptake, shows antidepressant efficacy.
709W92 potentiated head-twitch produced by 5-hydroxytryptophan, prevented head-twitch and whole brain 5-HT depletion produced by p-chloroamphetamine and rapidly decreased dorsal raphe firing.
709W92 showed anxiolytic activity in the rat-pup vocalization model of anxiety in vivo.

物理化学性质&存储条件

分子量	238.27
分子式	C15H11FN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-fluoro-3-[2-(4-pyridyl)vinyl]-1H-indole

参考文献

1. Salter M, et al. Neuropharmacology. 1995 Feb;34(2):217-27.

2. Salter M, et al. Adv Exp Med Biol. 1996;398:61-5.

709W92

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709W92

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