PVZB3001 | IDO1/TDO dual inhibitor | Probechem Biochemicals

Chemical Structure : PVZB3001

加入收藏

PVZB3001 (PVZB 3001)

货号: PC-49660Not For Human Use, Lab Use Only.

PVZB3001 (PVZB 3001) is a selective and cell-permeable dual inhibitor of IDO1 and TDO with IC50 value of 0.62 μM for rhTDO and 1.71 μM for rhIDO1, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PVZB3001 (PVZB 3001) is a selective and cell-permeable dual inhibitor of IDO1 and TDO with IC50 value of 0.62 μM for rhTDO and 1.71 μM for rhIDO1, respectively.
PVZB3001 inhibited cellular Kyn production dose-dependently in A172 cells and in A431 cells upon IFN-γ stimulation, with an IC50 value of 0.96 μM in A172 cells and 0.74 μM in A431 cells.
PVZB3001 showed competitive inhibition against TDO.
PVZB3001 recovered NK cell viability and function by inhibiting Kyn accumulation in conditioned medium of both IDO1- and TDO-expressing cells.
PVZB3001 suppressed the growth of tumor in a dose-dependent manner without body weight loss, especially showed significant antitumor effect when treated with 25.0 mg/kg (oral) and with 50.0 mg/kg (oral) respectively.

物理化学性质&存储条件

分子量	254.37
分子式	C10H14N4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,2-phenylenebis(methylene) dicarbamimidothioate

参考文献

1. Saeko Yoshioka, et al. Int J Tryptophan Res. 2022 Nov 30;15:11786469221138456.

PVZB3001 (PVZB 3001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PVZB3001 (PVZB 3001)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.