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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Tryptophan 2,3-Dioxygenase (TDO)-680C91
680C91

Chemical Structure : 680C91

CAS No.: 163239-22-3

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680C91 (TDO2 inhibitor 680C91)

货号: PC-49666Not For Human Use, Lab Use Only.

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) with Ki of 51 nM.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

680C91 is a potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) with Ki of 51 nM.
680C91 displays no activity against indoleamine 2,3-dioxygenase, monoamine oxidase A and B, 5-HT uptake or 5-HT1A, 1D, 2A and 2C receptors.
680C91 produces large increases in brain tryptophan and serotonin in vitro and in vivo in rats.

物理化学性质&存储条件

分子量 238.27
分子式 C15H11FN2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-6-fluoro-3-[2-(3-pyridyl)vinyl]-1H-indole

参考文献

1. Salter M, et al. Neuropharmacology. 1995 Feb;34(2):217-27.

2. Salter M, et al. Biochem Pharmacol. 1995 May 17;49(10):1435-42.

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