| Cat. No. |
Product Name |
Information |
| PC-20861 |
Org 274179-0
TSHR antagonist
|
Org 274179-0 is a highly potent, allosteric antagonist of the thyroid-stimulating hormone receptor (TSH receptor), inhibits bTSH-, hTSH- and M22-mediated CRE-luciferase transactivation in the CHO cell line. |
| PC-20501 |
NCGC00229600
TSHR inverse agonist
|
NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM. |
| PC-20500 |
NIDDK/CEB-52
TSHR antagonist
|
NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM. |
| PC-20498 |
SYD5115
TSH-R antagonist
|
SYD5115 (SYD-5115) is a potent, selective and orally bioavailable thyrotropin receptor (TSH-R) antagonist with IC50 of 48 and 62 nM for rTSHR and hTSHR, respectively. |
| PC-35977 |
ML-109
TSHR agonist
|
ML-109 (ML109, CID-25246343) is the first selective and orally available small-molecule thyroid stimulating hormone receptor (TSHR) agonist with EC50 of 40 nM. |
| PC-43013 |
ML224
TSHR inverse agonist
|
ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM. |
| PC-60808 |
NCGC00379308
TSHR modulator
|
NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation). |
| PC-21867 |
TSHR ligand A35
THSR ligand
|
TSHR ligand A35 (NCATS-SM4420, NCGC00241808) is a specific Thyroid-stimulating hormone receptor (Thyrotropin receptor, TSHR) ligand, selectively activates TSHR-mediated cAMP accumulation in HEK-TSHR with EC50 of 240 nM, inhibits thyroid cancer (TC) cell proliferation and metastasis. |
| PC-20499 |
NCGC00161856
TSHR inverse agonist
|
NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM. |
