ML224 |CAS:1338824-21-7 Probechem Biochemicals

Chemical Structure : ML224

CAS No.: 1338824-21-7

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ML224 (NCGC00242364, ANTAG3)

货号: PC-43013Not For Human Use, Lab Use Only.

ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
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生物&药学活性

ML224 (NCGC00242364, ANTAG3) is a potent selective thyroid stimulating hormone receptor (TSHR) inverse agonist, selectively inhibits TSH-stimulated cAMP production with IC50 of 2.3 uM.
ML224 (NCGC00242364, ANTAG3) inhibits TSHR basal activity with IC50 of 6.0 uM, displays >20-fold selectivity over LHR and FSHR.
ML224 (NCGC00242364, ANTAG3) inhibits stimulation of thyroid function in female mice.
ML224 (NCGC00242364, ANTAG3) is a potential lead for development of drugs to treat TSHR-mediated hyperthyroidism caused by constitutively activating mutations or stimulating auto-antibodies associated with Graves’ disease.

物理化学性质&存储条件

分子量	525.5949
分子式	C31H31N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[4-[[5-[3-(2-furanylmethyl)-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]-2-methoxyphenyl]methoxy]-3,5-dimethylphenyl]-

参考文献

1. Neumann S, et al. Endocrinology. 2014 Jan;155(1):310-4.

ML224 (NCGC00242364, ANTAG3)

生物&药学活性

物理化学性质&存储条件

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ML224 (NCGC00242364, ANTAG3)

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