NCGC00229600 | TSHR inverse agonist | Probechem Biochemicals

Chemical Structure : NCGC00229600

CAS No.: 1338824-20-6

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NCGC00229600 (NCGC 00229600)

货号: PC-20501Not For Human Use, Lab Use Only.

NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM.

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10 mg	￥3980	In stock
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生物&药学活性

NCGC00229600 is a small molecule, allosteric inverse agonist of TSH receptor (TSHR), inhibits basal cAMP production by TSHRs by 53% at 30 uM.
NCGC00229600 shows no effect on [125I]TSH binding to HEKTSHR cells, no effect on the binding of two monoclonal anti-TSHR antibodies, 2C11 and 4C1.
NCGC00229600 is an antagonist of basal and hTSH stimulation of hTSHR in human cells.
NCGC00229600 inhibits TSHR-mediated basal and GD sera up-regulation of thyroperoxidase mRNA levels by 65 ± 2.0% in primary cultures of human thyrocytes.

物理化学性质&存储条件

分子量	479.58
分子式	C30H29N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((2,6-dimethylphenoxy)methyl)-4-methoxyphenyl)-3-(pyridin-3-ylmethyl)-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Susanne Neumann, et al. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.

NCGC00229600 (NCGC 00229600)

生物&药学活性

物理化学性质&存储条件

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NCGC00229600 (NCGC 00229600)

生物&药学活性

物理化学性质&存储条件

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