NIDDK/CEB-52 | TSHR antagonist | Probechem Biochemicals

Chemical Structure : NIDDK/CEB-52

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NIDDK/CEB-52 (Compound 52)

货号: PC-20500Not For Human Use, Lab Use Only.

NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM.

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生物&药学活性

NIDDK/CEB-52 (Compound 52) is a potent and selective antagonist for TSH receptor (TSHR), inhibits TSH-mediated cAMP response of TSHR with IC50 of 4.2 uM.
NIDDK/CEB-52 is selective toward TSHR when compared with the closely related LHCGR and FSHR.
NIDDK/CEB-52 (10 and 30 uM) inhibits TSH stimulation of TPO mRNA expression in human thyrocytes.
NIDDK/CEB-52 (30 uM) inhibits TSHR activation by thyroid-stimulating antibodies (TsAbs) from patients with Graves' disease.

物理化学性质&存储条件

分子量	442.60
分子式	C22H26N4O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=C(N)C2=C(C3=CC=C(/C=C/COC)C=C3)N=C(SC)N=C2S1)NC(C)(C)C

参考文献

1. Susanne Neumann, et al. Endocrinology. 2008 Dec;149(12):5945-50.

NIDDK/CEB-52 (Compound 52)

生物&药学活性

物理化学性质&存储条件

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NIDDK/CEB-52 (Compound 52)

生物&药学活性

物理化学性质&存储条件

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