NCGC00379308 |CAS:662164-09-2 Probechem Biochemicals

Chemical Structure : NCGC00379308

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NCGC00379308 (D3-βArr;NCGC-00379308;NCGC 00379308)

货号: PC-60808Not For Human Use, Lab Use Only.

NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).

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生物&药学活性

NCGC00379308 (D3-βArr) is a potent, functionally selective TSH receptor (TSHR) positive allosteric modulator with EC50 of 11.6 uM (β-Arr 1 translocation).
NCGC00379308 (D3-βArr) does not activate β-Arr 1 translocation to the GLP1R, binds and activates the TSHR and has no agonistic effect on cAMP production nor inhibit TSH-induced cAMP production in DiscoverX1 cells and primary cultures of human thyrocytes.
NCGC00379308 (D3-βArr) potentiates TSH-induced upregulation of ALPL and OPN mRNA levels, and increases TSH-induced secretion of OPN protein.
NCGC00379308 (D3-βArr) potentiates the effect of TSH to enhance differentiation of a human preosteoblast in an in vitro model.

物理化学性质&存储条件

分子量	333.439
分子式	C20H23N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine

参考文献

1. Neumann S, et al. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45.

NCGC00379308 (D3-βArr;NCGC-00379308;NCGC 00379308)

生物&药学活性

物理化学性质&存储条件

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NCGC00379308 (D3-βArr;NCGC-00379308;NCGC 00379308)

生物&药学活性

物理化学性质&存储条件

参考文献

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