NCGC00161856 | TSHR inverse agonist | Probechem Biochemicals

Chemical Structure : NCGC00161856

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NCGC00161856 (NCGC 00161856)

货号: PC-20499Not For Human Use, Lab Use Only.

NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM.

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生物&药学活性

NCGC00161856 is the first small-molecule ligand and inverse agonist of TSHR, inhibits basal cAMP production by TSHR in HEK-EM 293 cells stably expressing TSHRs with IC50 of 3.0 uM.
NCGC00161856 also inhibits TSH-stimulated cAMP production with IC50 of 0.78 uM.
NCGC00161856 is a competitive antagonist of TSH-stimulated signaling.
NCGC00161856 (30 uM) inhibits the basal expression of mRNAs for TPO, TSHR, TG, NIS, and DIO2 in primary cultures of human thyrocytes.

物理化学性质&存储条件

分子量	468.55
分子式	C29H28N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C1N(CC2=CC=CO2)C(C3=CC=C(OC)C(COC4=C(C)C=CC=C4C)=C3)NC5=C1C=CC=C5

参考文献

1. Neumann S, et al. Endocrinology 151:3454–3459.

NCGC00161856 (NCGC 00161856)

生物&药学活性

物理化学性质&存储条件

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NCGC00161856 (NCGC 00161856)

生物&药学活性

物理化学性质&存储条件

参考文献

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