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首页-小分子抑制剂&激动剂-Others-Spliceosome

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Cat. No. Product Name Information
PC-49818

BPN15477

ELP1 splicing modulator

BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays.
PC-49817

PTC258

ELP1 splicing modulator

PTC-258 (PTC258) is a highly potent, specific and orally active ELP1 splicing modulator, efficiently increases full-length ELP1 mRNA and protein in FD patient fibroblasts (EC2X ELP1 protein=0.34 nM).
PC-73332

HTT-D3

HTT splicing modulator

HTT-D3 is a potent, CNS-penetrant, orally bioavailable huntingtin (HTT) splicing modulator, affects HTT pre-mRNA splicing and reduces HTT expression with IC50 of 8 nM.
PC-73327

CD33 splicing modulator 1

CD33 splicing modulator

CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.
PC-73221

Thailanstatin B

Splicing inhibitor

Thailanstatin B is a potent antiproliferative natural product and pre-mRNA splicing inhibitor, potential antibody-drug conjugate payload.
PC-72336

No. 10-3

PSF inhibitor

No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM).
PC-72029

UHMCP1

SF3b155/U2AF65 inhibitor

UHMCP1 is a small molecule that prevents the SF3b155/U2AF65 interaction, binds to the hydrophobic pocket of the U2AF65 UHM domain (Kd=1-20 uM), impacts splicing and cell viability.
PC-38057

Thailanstatin C

Splicing inhibitor

Thailanstatin C (TST-C) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent..
PC-38056

Thailanstatin A

Splicing inhibitor

Thailanstatin A (TST-A) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent..
PC-38037

FR901465

Splicing modulator

FR901465 is an antitumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663, a splicing modulator with strong anticancer activities..
PC-36117

VPC-80051

hnRNP A1 splicing inhibitor

VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1.
PC-62862

Herboxidiene

SF3B inhibitor

Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome.

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