欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-WX-02-23
WX-02-23

Chemical Structure : WX-02-23

CAS No.: 2929223-35-6

加入收藏

WX-02-23

货号: PC-22145Not For Human Use, Lab Use Only.

WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds cysteine (C258) and promotes the stereoselective and site-specific binding of FOXA1 to DNA.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds cysteine (C258) and promotes the stereoselective and site-specific binding of FOXA1 to DNA.
WX-02-23 stereoselectively blocks CJR-6A reactivity with purified MBP-FOXA1-FKHD protein in the presence of oligonucleotide with IC50 of 8 uM.
WX-02-23 causes the rapid redistribution of FOXA1 across chromatin.

物理化学性质&存储条件

分子量 459.50
分子式 C26H25N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-((1R,3S)-1-(benzo[d][1,3]dioxol-5-yl)-3-(morpholine-4-carbonyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)prop-2-en-1-one

参考文献

1. Won SJ, et al. bioRxiv. 2024 Mar 21:2024.03.21.586158.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: