AP232 | U2AF1-UHM inhibitor | Probechem Biochemicals

Chemical Structure : AP232

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AP232 (AP-232)

货号: PC-25819Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

AP232 is a specific small molecule splicing factor U2AF-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM).
AP232 has 31-fold improvement in the IC50 value than SF153 (Cat# PC-25479) against U2AF1-UHM based on the HTRF assay.
AP232 potently inhibits growth in HNT-34 (IC50 = 6.49 ± 0.38 μM) and MONO-MAC-1 (IC50 = 14.09 uM).
AP232 (20 uM) 2markedly increased the G2/M population in NKM-1 cells at 48 h.
AP232 impares lysosome acidification and autophagy in leukemia cells.

物理化学性质&存储条件

分子量	329.49
分子式	C20H31N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(4-ethoxy-1H-indol-3-yl)butan-2-yl)-4-methylpiperidin-4-amine

参考文献

1. Patil AD, et al. ACS Med Chem Lett. 2025 Sep 11;16(10):2015-2021.

AP232 (AP-232)

生物&药学活性

物理化学性质&存储条件

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AP232 (AP-232)

生物&药学活性

物理化学性质&存储条件

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