No. 10-3 | PSF inhibitor | Probechem Biochemicals

Chemical Structure : No. 10-3

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No. 10-3 (PSF inhibitor No. 10-3)

货号: PC-72336Not For Human Use, Lab Use Only.

No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM).

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生物&药学活性

No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM).
No. 10-3 inhibited the PSF-mediated RNA splicing and the epigenetic pathway that promotes apoptosis and inhibits cell cycle in both breast and prostate cancer cells.
Pharmacologic inhibition of PSF function by No. 10-3 impaired tumor growth in a xenograft mouse model of treatment-resistant prostate cancer.
RNA-binding protein PSF functions as an epigenetic modifier by interacting with long noncoding RNAs and the corepressor complex. PSF also promotes RNA splicing events to enhance oncogenic signals.

物理化学性质&存储条件

分子量	284.267
分子式	C16H12O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7,8-dihydroxy-4-(4-methoxyphenyl)chromen-2-one

参考文献

1. Ken-Ichi Takayama, et al. Cancer Res. 2021 Jul 1;81(13):3495-3508.

No. 10-3 (PSF inhibitor No. 10-3)

生物&药学活性

物理化学性质&存储条件

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No. 10-3 (PSF inhibitor No. 10-3)

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物理化学性质&存储条件

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