CD33 splicing modulator 1

Chemical Structure : CD33 splicing modulator 1

加入收藏

货号: PC-73327Not For Human Use, Lab Use Only.

CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein.
CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity.
CD33 splicing modulator 1 reduces full-length V-domain containing CD33 protein in meyloid lineage cells (EC50=2.1 uM), increases exon 2 skipping in cellular mRNA pools.

物理化学性质&存储条件

分子量	444.514
分子式	C25H25FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methylpyridin-2-yl)-N-(piperidin-3-yl)benzamide

参考文献

1. Thomas A Chappie, et al. ACS Med Chem Lett. 2022 Jan 4;13(1):55-62.