| Cat. No. |
Product Name |
Information |
| PC-61443 |
Rivipansel sodium
pan-Selectin inhibitor
|
Rivipansel sodium (GMI-1070, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively. |
| PC-61287 |
PSI-421
P-selectin inhibitor
|
PSI-421 is a potent, orally bioavailable P-selectin inhibitor with biacore IC50 of 56 uM, shows improved pharmacokinetic properties and oral efficacy in models of vascular injury compare with PSI-697. |
| PC-61286 |
GMI-1070
pan-Selectin inhibitor
|
GMI-1070 (Rivipansel, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively. |
| PC-61285 |
GMI-1271
E-Selectin inhibitor
|
GMI-1271 (Uproleselan sodium) is a specific glycomimetic E-Selectin antagonist with Kd of 0.46 uM, IC50 of 1.75 uM. |
| PC-60181 |
HMCEF
P-selectin inhibitor
|
HMCEF is a small molecule P-selectin inhibitor that directly binds to P-selectin, intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells. |
| PC-22341 |
PSI-697
P-selectin inhibitor
|
PSI-697 is a potent, selective and orally bioavailable P-selectin antagonist with biacore IC50 of 150 uM. |
| PC-61284 |
GMI-1257
|
A dual inhibitor of E selectin and CXCR4 with IC50 of 3.6 uM and 1.1 uM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice. |
| PC-61283 |
GMI-1215
|
A dual inhibitor of E selectin and CXCR4 with IC50 of 4.1 uM and 30 nM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice. |
