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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Selectin-GMI-1257
GMI-1257

Chemical Structure : GMI-1257

CAS No.:

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GMI-1257 (GMI1257)

货号: PC-61284Not For Human Use, Lab Use Only.

A dual inhibitor of E selectin and CXCR4 with IC50 of 3.6 uM and 1.1 uM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

A dual inhibitor of E selectin and CXCR4 with IC50 of 3.6 uM and 1.1 uM respectively, blocks adhesion of AML blasts to E-Selectin, mobilizes human AML engrafted in mice; inhibits E-selectin and SDF-1 mediated chemotaxis in a transwell-based assay, effectively mobilizes leukemia from the marrow and reduces the bone marrow burden of AML in combination with chemotherapy.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Sylvia Chien, et al. Blood 2011 118:579.

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