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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Selectin-HMCEF
HMCEF

Chemical Structure : HMCEF

CAS No.: 2002363-68-8

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HMCEF (P-selectin inhibitor)

货号: PC-60181Not For Human Use, Lab Use Only.

HMCEF is a small molecule P-selectin inhibitor that directly binds to P-selectin, intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HMCEF is a small molecule P-selectin inhibitor that directly binds to P-selectin, intercalates into calf thymus DNA, cuts off DNA pBR22 and inhibits the proliferation of cancer cells.
    HMCEF dose dependently inhibits inflammatory response of mice and inhibits thrombosis and inflammation, decreases serum TNFα and IL-8.

    物理化学性质&存储条件

    分子量 389.455
    分子式 C23H23N3O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2-(3-(hydroxymethyl)-9H-pyrido[3,4-b]indol-1-yl)ethyl)-L-phenylalanine

    参考文献

    1. Wu J, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4631-6.

    2. Wu J, et al. Drug Des Devel Ther. 2017 Jan 17;11:225-239.

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