PSI-697 | P-selectin inhibitor | Probechem Biochemicals

Chemical Structure : PSI-697

CAS No.: 851546-61-7

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PSI-697 (PSI 697)

货号: PC-22341Not For Human Use, Lab Use Only.

PSI-697 is a potent, selective and orally bioavailable P-selectin antagonist with biacore IC50 of 150 uM.

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10 mg	￥4580	In stock
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生物&药学活性

PSI-697 is a potent, selective and orally bioavailable P-selectin antagonist with biacore IC50 of 150 uM.
PSI-697 dose dependently inhibits the binding of human P-selectin to human P-selectin glycoprotein ligand-1, inhibiting 50% of binding at 50 to 125 microM.
PSI-697 shows oral efficacy in mouse and rat models of atherogenesis and vascular injury.
PSI-697 (50 mg/kg p.o.) significantly reduced the number of rolling leukocytes by 39% (P < 0.05) versus vehicle control in surgical inflammation rat model.
PSI-697 (100 mg/kg p.o.) reduced thrombus weight by 18% (P < 0.05) relative to vehicle, without prolonging bleeding time, in rat venous thrombosis model.

物理化学性质&存储条件

分子量	367.83
分子式	C21H18ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid

参考文献

1. Kaila N, et al. J Med Chem. 2007 Jan 11;50(1):40-64.

2. Bedard PW, et al. J Pharmacol Exp Ther. 2008 Feb;324(2):497-506.

PSI-697 (PSI 697)

生物&药学活性

物理化学性质&存储条件

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PSI-697 (PSI 697)

生物&药学活性

物理化学性质&存储条件

参考文献

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