| Cat. No. |
Product Name |
Information |
| PC-24633 |
STING inhibitor SI-43
STING inhibitor
|
STING inhibitor SI-43 is a potent small molecule inhibitor of stimulator of interferon genes (STING) with IC50 of 0.11 uM against cGAMP-induced STING activation in THP1-Blue ISG cells. |
| PC-24614 |
TAK-676
STING agonist
|
TAK-676 (Dazostinag disodium) is a potent, selective stimulator of interferon genes (STING) agonist with highly selective binding and activation of STING proteins from various species, with Kd values of 0.01 uM, 0.008 uM, 0.011 uM, and 0.027 uM for mouse, rat, cynomolgus monkey, and human STING orthologs, respectively. |
| PC-22806 |
SNX281
STING agonist
|
SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. |
| PC-22439 |
STING degrader AK59
STING degrader
|
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation. |
| PC-22431 |
BDW568
STING agonist
|
BDW568 is a non-nucleotide agonist of human STING (stimulator of interferon genes) and type-I interferon signaling activator. |
| PC-21582 |
NVS-STG2
STING agonist
|
NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells. |
| PC-21157 |
LB244
STING inhibitor
|
LB244 (LB-244) is a highly potent, selective and irreversible STING antagonist, blocks STING oligomerization and inhibits STING signaling THP1 dual cells with IC50 of 0.8 uM. |
| PC-20989 |
DWL-4-140
STING inhibitor
|
DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM. |
| PC-20020 |
SB24011
STING-TRIM29 inhibitor
|
SB24011 (SB 24011) is a selective small molecule inhibitor of the STING-TRIM29 interaction with IC50 of 3.85 uM in luciferase complementation assays, enhances cGAMP-mediated STING immunity. |
| PC-49595 |
HB3089
STING agonist
|
HB3089 (HB-3089) is a novel potent, highly specific STING agonist, dose-dependently activates interferon-stimulated gene (ISG) signaling in THP1-Dual reporter cells with EC50 of 1-10 uM. |
| PC-49313 |
BSP16
STING agonist
|
BSP16 (LF250) is a potent, orally available STING agonist, strongly activates STING signaling in human and mouse cells and binds STING as a homodimer. |
| PC-38729 |
SHR1032
STING agonist
|
SHR1032 is a novel small molecule non-cyclic di-nucleotide STING agonist, exhibits significantly high affinity binding to STING and cellular reporter assay (EC50=30 nM). |
