| Cat. No. |
Product Name |
Information |
| PC-27124 |
STING agonist C92
STING agonist
|
STING agonist C92 is a potent, allosteric hSTING agonist with EC50 of 36.2 nM for enhancement of the association of [3H]cGAMP (1 nM) to STING. |
| PC-27088 |
INI3069
STING agonist
|
INI3069 is a human-selective STING agonist, inhibits trafficking of STING to the Golgi and blocks STING-mediated TFEB dephosphorylation and autophagy, enhances both humoral responses to co-administered antigen and anti-tumor responses. |
| PC-24633 |
STING inhibitor SI-43
STING inhibitor
|
STING inhibitor SI-43 is a potent small molecule inhibitor of stimulator of interferon genes (STING) with IC50 of 0.11 uM against cGAMP-induced STING activation in THP1-Blue ISG cells. |
| PC-24614 |
TAK-676
STING agonist
|
TAK-676 (Dazostinag disodium) is a potent, selective stimulator of interferon genes (STING) agonist with highly selective binding and activation of STING proteins from various species, with Kd values of 0.01 uM, 0.008 uM, 0.011 uM, and 0.027 uM for mouse, rat, cynomolgus monkey, and human STING orthologs, respectively. |
| PC-23967 |
Astin C
STING inhibitor
|
Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling. |
| PC-22806 |
SNX281
STING agonist
|
SNX281 is a systemically active STING agonist that binds to the STING protein, promotes signal transduction of the cGAS-STING pathway, and increases cellular responses to tumor cells. |
| PC-38078 |
SN-011
STING inhibitor
|
SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition). |
| PC-22439 |
STING degrader AK59
STING degrader
|
STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation. |
| PC-22431 |
BDW568
STING agonist
|
BDW568 is a non-nucleotide agonist of human STING (stimulator of interferon genes) and type-I interferon signaling activator. |
| PC-21582 |
NVS-STG2
STING agonist
|
NVS-STG2 is a small molecule STING agonist with AC50 of 5.2 uM in ISRE-Luc reporter assays, induces STING-dependent IRF3 phosphorylation in THP1 cells. |
| PC-21157 |
LB244
STING inhibitor
|
LB244 (LB-244) is a highly potent, selective and irreversible STING antagonist, blocks STING oligomerization and inhibits STING signaling THP1 dual cells with IC50 of 0.8 uM. |
| PC-20989 |
DWL-4-140
STING inhibitor
|
DWL-4-140 is a small molecule inhibitor of cyclized nucleotide-binding domain (CBD) of STING, selectively inhibits DNA-mediated IFNβ responses with IC50 of 617 nM. |
