SN-011 | STING inhibitor | Probechem Biochemicals

Chemical Structure : SN-011

CAS No.: 2249435-90-1

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SN-011 (SN011)

货号: PC-38078Not For Human Use, Lab Use Only.

SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition).

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

SN-011 (SN011) is a potent, selective STING antagonist with IC50 of 76 nM (STING signaling inhibition).
SN-011 binds with higher affinity (Kd=4.03 nM) to the cyclic dinucleotide (CDN)-binding pocket of STING than endogenous 2'3'-cGAMP (Kd=9.23 nM).
SN-011 (1 μM) significantly suppresses the induction of Ifnb, Cxcl10, and Il6 mRNA in MEFs activated by various canonical STING stimulators (ISD, HT-DNA, HSV-1, c-di-GMP, and 2′3′-cGAMP).
SN-011 specifically inhibits STING activation and STING-dependent signaling.
SN-011 suppresses systemic inflammation and death in Trex1−/− mice.

物理化学性质&存储条件

分子量	462.495
分子式	C25H19FN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((4-fluorophenyl)sulfonamido)-4-hydroxyphenyl)-[1,1'-biphenyl]-4-carboxamide

参考文献

1. Hong Z, et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.

SN-011 (SN011)

生物&药学活性

物理化学性质&存储条件

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SN-011 (SN011)

生物&药学活性

物理化学性质&存储条件

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