| Cat. No. |
Product Name |
Information |
| PC-24803 |
SR-301
STING agonist
|
SR-301 is a potent, non-nucleotide, oral small-molecule STING agonist with EC50 of 0.6 uM. |
| PC-24802 |
ZSA-215
STING agonist
|
ZSA-215 is a potent oral STING agonist with EC50 of 3.3 uM, enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-β. |
| PC-24613 |
MK-2118
STING agonist
|
MK-2118 is a highly potent, noncyclic dinucleotide STING agonist. |
| PC-24587 |
HG381
STING agonist
|
HG381 is a new-generation, non-CDN STING agonist. |
| PC-24586 |
STING agonist A4
STING agonist
|
STING agonist A4 is a potent, specific STING agonist, effectively activates STING in both human THP1 and mouse RAW 264.7 cells with EC50 values of 0.06 and 14.15 μM, respectively. |
| PC-24560 |
STING agonist 12b
STING agonist
|
STING agonist 12b is a small molecule STING agonist with EC50 of 7.45 uM and 10.23 uM for human and murine STING respectively and Emax>100% for both, directly binds to carboxy-terminal domain (CTD) (IC50=1.92 uM) and stabilizes the hSTING protein. |
| PC-24559 |
STING synergist 67
STING synergist
|
STING synergist 67 is a selective STING synergist with EC50 of 20.5 uM, binds to carboxy-terminal domain (CTD) of STING (SPR KD=12.2 uM), amplifies cGAMP-induced pathway activation without inherent agonist properties. |
| PC-24094 |
Excavatolide B
STING inhibitor
|
Excavatolide B (ExcB) is a marine diterpenoid of covalent STING inhibitor, covalently engages STING at its membrane-proximal Cys91, inhibits STING palmitoylation and signaling, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 12.1 uM. |
| PC-24093 |
GHN105
STING inhibitor
|
GHN105 is a specific, orally bioavailable, covalent STING inhibitor, selectively targets the membrane-proximal Cys91 residue of STING, inhibits IFN-β levels in culture supernatants of THP1 macrophages with IC50 of 4.4 uM. |
| PC-24084 |
E7766 diammonium salt
STING agonist
|
E7766 diammonium salt is a macrocycle-bridged STING agonist with ITC Kd of 40 nM, exhibits broad pan-genotypic activity in all major human STING variants. |
| PC-23967 |
Astin C
STING inhibitor
|
Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling. |
| PC-23966 |
STING inhibitor 42
STING inhibitor
|
STING inhibitor 42 is a potent, orally bioavailable STING inhibitor with IC50 of 34.2 nM and 7.1 nM for human and murine STING respectively. |
