STING inhibitor 18 | STING inhibitor | Probechem Biochemicals

Chemical Structure : STING inhibitor 18

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STING inhibitor 18 (STING ligand-1)

货号: PC-24981Not For Human Use, Lab Use Only.

STING inhibitor 18 is a potent, orthosteric STING inhibitor / antagonist with IC50 of 68 nM in HAQ STING cGAMP displacement assay.

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生物&药学活性

STING inhibitor 18 is a potent, orthosteric STING inhibitor / antagonist with IC50 of 68 nM in HAQ STING cGAMP displacement assay.
STING inhibitor 18 displace cGAMP and stabilize the “open” conformation of STING, a key assumption is that stabilizing the “open” conformation will prevent all STING signaling.
STING inhibitor 18 exhibits good oral exposure, slow binding kinetics, and functional inhibition of STING-mediated cytokine release.

物理化学性质&存储条件

分子量	523.99
分子式	C29H27ClFNO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3S,4S)-2-(4-(tert-butyl)-3-chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl)acetic acid

参考文献

1. Tony Siu, et al. ACS Med Chem Lett. 2018 Dec 6;10(1):92-97.

STING inhibitor 18 (STING ligand-1)

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物理化学性质&存储条件

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STING inhibitor 18 (STING ligand-1)

生物&药学活性

物理化学性质&存储条件

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