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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-KSI-028
KSI-028

Chemical Structure : KSI-028

CAS No.:

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KSI-028 (KSI 028, KSI028)

货号: PC-26568Not For Human Use, Lab Use Only.

KSI-028 is a potent, specific STING inhibitor with IC50 of 0.652 uM in reporter assay in RAW264.7 cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KSI-028 is a potent, specific STING inhibitor with IC50 of 0.652 uM in reporter assay in RAW264.7 cells.
KSI-028 markedly attenuated the activity induced by cGAMP or MSA-2 in a dose-dependent manner in ISRE reporter assay.
KSI-028 inhibited innate immune responses in a dose-dependent manner, effectively suppressed IFN-β production.
KSI-028 markedly reduced the phosphorylation of STING, TBK1, IRF3, and STAT1 following stimulation with either cGAMP or MSA-2.
KSI-028 (30 mg/kg) alleviated cisplatin-induced AKI in vivo.

物理化学性质&存储条件

分子量 398.39
分子式 C18H14N4O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(1-(Isothiazole-5-carbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-5-nitrofuran-2-carboxamide

参考文献

1. Jeong SH, et al. J Med Chem. 2026 Apr 18. doi: 10.1021/acs.jmedchem.6c00162.

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