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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-SH-273
SH-273

Chemical Structure : SH-273

CAS No.: 3084159-97-4

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SH-273 (SH273)

货号: PC-26653Not For Human Use, Lab Use Only.

SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SH-273 is a dual functional compound that simultaneously activate STING and inhibit PI3Kγ, stimulates STING activity (IC50=29.6 nM) in THP-1 Blue ISG cells (STING reporter) and inhibited PI3Kγ (IC50=20.2 nM).
SH-273 abolished the STING-induced IRF3 phosphorylation in B cells from splenocytes of KPC PDAC mice.
SH-273 eliminated STING-induced expansion of IL35+ and IL10+ Breg cells in the splenocytes from KPC mice.
Albumin nanoformulation of SH-273 (Nano-273) decreases Breg cells and remodels microenvironment in tumors and lymph nodes, extended median survival to 200 days in transgenic KPC PDAC mice (KrasG12D-P53R172H-Cre) when combined with anti-PD-1.

物理化学性质&存储条件

分子量 852.88
分子式 C43H36N10O8S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(4-(3-(1-(2-aminopyrazolo[1,5-a]pyrimidine-3-carboxamido)ethyl)-1-oxo-2-phenyl-1,2-dihydroisoquinolin-8-yl)-1H-1,2,3-triazol-1-yl)ethyl 3-(6,7-dimethoxy-1,3-dioxo-1,3-dihydro-2H-benzo[4,5]thieno[2,3-c]pyrrol-2-yl)propanoate

参考文献

1. Li C, et al. Dual targeting of PI3Kγ and STING overcomes regulatory B cell- and myeloid cell-driven immune suppression in pancreatic cancer. Nat Cancer. 2026 Apr 28. doi: 10.1038/s43018-026-01158-7.

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