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首页-小分子抑制剂&激动剂-Immunology/Inflammation-STING-Astin C
Astin C

Chemical Structure : Astin C

CAS No.: 148057-23-2

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Astin C (Asterin)

货号: PC-23967Not For Human Use, Lab Use Only.

Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling.

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2 mg ￥1880 In stock
5 mg ￥2880 In stock
10 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Astin C is a specific, cyclopeptide inhibitor of cGAS-STING signaling, binds to STING C-terminal binding domain (CBD) with Kd of 2.37 uM (STING-CTD-H232), blocks the recruitment of IRF3 onto the STING signalosome and restricts STING activation and signaling.
Astin C exhibits inhibitory effect on intracellular DNA-induced Ifnb expression is dose dependent, with IC50 (half maximal inhibitory concentration) values of 3.42 and 10.83 μM for mouse embryonic fibroblasts (MEFs) and IMR-90 cells (human fetal lung fibroblasts), respectively.
Astin C markedly attenuates the autoinflammatory responses in Trex1-/- BMDM cells and in Trex1-/- mouse autoimmune disease model.

物理化学性质&存储条件

分子量 570.47
分子式 C25H33Cl2N5O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

17,18-Dichloro-3,13-diethyl-10-(hydroxymethyl)-7-phenyl-1,4,8,11,14-pentazabicyclo[14.3.0]nonadecane-2,5,9,12,15-pentone

参考文献

1. Li S, et al. Cell Rep. 2018 Dec 18;25(12):3405-3421.e7.

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