STING degrader AK59 (AK59-51TB)

Chemical Structure : STING degrader AK59

CAS No.:

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货号: PC-22439Not For Human Use, Lab Use Only.

STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

STING degrader AK59 (AK59-51TB) is a small molecule STING degrader leveraging HECT-domain E3 ligase HERC4, inhibits the cGAS/STING pathway via degradation of STING by proteasomal degradation.
AK59-51TB able to induce the degradation of STING-SAVI mutants, induces STING degradation in CD14+ human PBMCs.
AK59-mediated STING degradation acts through the UPS involving HERC4, UBA5, and UBA6 as regulatory factors.
AK59 degrades STING by inducing its interaction with the E3 ligase HERC4.

物理化学性质&存储条件

分子量	429.42
分子式	C21H14F3N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(pyridin-3-yl)quinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide

参考文献

1. Mutlu M, et al. Nat Commun. 2024 May 29;15(1):4584.