| Cat. No. |
Product Name |
Information |
| PC-21770 |
TH6342
SAMHD1 inhibitor
|
TH6342 (TH-6342) is a specific small-molecule inhibitor against the dNTP triphosphohydrolase (dNTPase) SAMHD1, inhibits the enzymatic activities of SAMHD1 against dGTP, Cl-F-ara-ATP, and ara-CTP with IC50 of 9.6, 11.0 and 5.8 uM, respectively. |
| PC-20288 |
TCP2 inhibitor 163
TDP2 inhibitor
|
TCP2 inhibitor 163 (Deazaflavin 163) is a potent, selective inhibitor of tyrosyl-DNA-phosphodiesterases 2 (TDP2) with EC50 of 40 nM in NPPP assays, shows selectivity against TDP1 and APE-1. |
| PC-20287 |
JLT048
TDP1/2 inhibitor
|
JLT048 is a small molecule inhibitor of tyrosyl-DNA-phosphodiesterases 1 and 2 (TDP1 and TDP2) with IC50 of 7.7 and 32 uM, respectively. |
| PC-20268 |
Teriflunomide
DHODH inhibitor
|
Teriflunomide (RS-61980, A771726) is the active metabolite of leflunomide, acts as an immunomodulatory agent by inhibiting pyrimidine synthesis, inhibits dihydroortate dehydrogenase (DHODH, EC 1.3.3.1) with IC50 of 2.7 uM. |
| PC-20259 |
Pyrazofurin
OMP decarboxylase inhibitor
|
Pyrazofurin (Pyrazomycin, NSC 143095) is a nucleoside analog that potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity. |
| PC-20257 |
Acivicin hydrochloride
GATases inhibitor
|
Acivicin hydrochloride (AT-125, U-42,126, NSC 163501) is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20256 |
Acivicin
GATases inhibitor
|
Acivicin is an analog of glutamine and inhibits glutamine amidotransferases (GATases) in the purine and pyrimidine biosynthetic pathways. |
| PC-20254 |
N-phosphonacetyl-L-aspartate
ATCase inhibitor
|
N-phosphonacetyl-L-aspartate (PALA, NSC 224131, Sparfosic acid) is a potent and reversible inhibitor of de novo pyrimidine biosynthesis, specifically inhibits aspartate transcarbamylase (ATCase). |
| PC-20182 |
dCK inhibitor DI-39
dCK inhibitor
|
DI-39 is a compound that inhibits the salvage pathways by blocking the enzyme, deoxycytidine kinase (dCK), induces replication stress in ALL cancer cell models through dCTP depletion. |
| PC-49673 |
PSB-071
NTPDase inhibitor
|
PSB-071 (PSB071) is a small molecule inhibitor of nucleoside triphosphate diphosphohydrolases (NTPDase). |
| PC-49655 |
PSB-0952
CD73 inhibitor
|
PSB-0952 (PSB0952) is a potent, selective ecto-5'-Nucleotidase (eN, CD73) inhibitor with Ki of 260 nM, >150-fold selectivity over NTPDases and P2Y receptor subtypes P2Y2, P2Y4, P2Y6, and P2Y12. |
| PC-49654 |
PSB-0963
CD73 inhibitor
|
PSB-0963 (PSB0963) is a potent, selective ecto-5'-Nucleotidase (eN, CD73) inhibitor with Ki of 150 nM, >100-fold selectivity over NTPDases. |
