OR0642 | dCK inhibitor | Probechem Biochemicals

Chemical Structure : OR0642

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OR0642 (OR-0642)

货号: PC-22531Not For Human Use, Lab Use Only.

OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.

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生物&药学活性

OR0642 is a highly potent, specific deoxycytidine kinase (dCK) inhibitor with IC50 of 2.2 nM.
OR0642 is more than 1000 times more potent than its initial parent compound, masitinib.
OR0642 in combination with a physiological inhibitor of the de novo pathway doubled the survival rate in a human T-cell acute lymphoblastic leukemia patient-derived xenograft mouse model.

物理化学性质&存储条件

分子量	646.75
分子式	C29H33F3N8O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((4-methyl-4'-((4-methylpiperazin-1-yl)sulfonyl)-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)(propyl)amino)thiazol-4-yl)pyrimidine-4,6-diamine

参考文献

1. Magali Saez-Ayala, et al. Nat Commun. 2023 May 29;14(1):3079.

OR0642 (OR-0642)

生物&药学活性

物理化学性质&存储条件

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OR0642 (OR-0642)

生物&药学活性

物理化学性质&存储条件

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