TH6342 | SAMHD1 inhibitor | Probechem Biochemicals

Chemical Structure : TH6342

CAS No.:

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TH6342 (TH 6342, TH-6342, CBK037371)

货号: PC-21770Not For Human Use, Lab Use Only.

TH6342 (TH-6342) is a specific small-molecule inhibitor against the dNTP triphosphohydrolase (dNTPase) SAMHD1, inhibits the enzymatic activities of SAMHD1 against dGTP, Cl-F-ara-ATP, and ara-CTP with IC50 of 9.6, 11.0 and 5.8 uM, respectively.

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5 mg	￥680	In stock
10 mg	￥980	In stock
25 mg	￥1680	In stock
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100 mg		Get quote

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生物&药学活性

TH6342 (TH-6342) is a specific small-molecule inhibitor against the dNTP triphosphohydrolase (dNTPase) SAMHD1, inhibits the enzymatic activities of SAMHD1 against dGTP, Cl-F-ara-ATP, and ara-CTP with IC50 of 9.6, 11.0 and 5.8 uM, respectively.
TH6342 shows high selectivity against a panel of nucleotide phosphatases.
TH6342 impeded GTP-induced dimerization and thereafter activation, delayed the allosteric activation of SAMHD1.
TH6342 inhibited SAMHD1 hydrolase activity in vitro with low μM potencies and high selectivity, ia a mode of inhibition that deters efficient allosteric activation of SAMHD1 without occupying (d)NTP binding pockets.

物理化学性质&存储条件

分子量	349.82
分子式	C19H16ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-chlorophenyl)-N-(2-(pyridin-2-yl)ethyl)imidazo[1,2-a]pyrazin-8-amine

参考文献

1. Si Min Zhang, et al. iScience. 2024 Jan 13;27(2):108907.

TH6342 (TH 6342, TH-6342, CBK037371)

生物&药学活性

物理化学性质&存储条件

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TH6342 (TH 6342, TH-6342, CBK037371)

生物&药学活性

物理化学性质&存储条件

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