| Cat. No. |
Product Name |
Information |
| PC-22673 |
S1g-10
Hsp70-Bim inhibitor
|
S1g-10 is a potent Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 688 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance in CML in vivo. |
| PC-22570 |
KUNB106
Hsp90β inhibitor
|
KUNB106 is a potent, highly selective Hsp90β inhibitor with KD of 91 nM, >275-fold selectivity vs. other isoforms. |
| PC-22213 |
NCT-58
HSP90 inhibitor
|
NCT-58 is a specfiic small molecule C-terminal HSP90 inhibitor, kills trastuzumab-resistant HER2-positive breast cancer stem-like cells, targets the C-terminal HSP90 without inducing heat shock response (HSR). |
| PC-21759 |
HYOU1 inhibitor 52
HYOU1 inhibitor
|
HYOU1 inhibitor 52 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 0.57 uM. |
| PC-21758 |
HYOU1 inhibitor 33
HYOU1 inhibitor
|
HYOU1 inhibitor 33 is a first-in-class inhibitor for Hypoxia up-regulated protein 1 (HYOU1, GRP170/ORP150), decreases significantly the levels of the cytokine Interleukin 6 (IL-6) in LPS (10 ng/mL)-treated WT-MΦs with IC50 of 2.57 uM. |
| PC-21297 |
BX-2819
HSP90 inhibitor
|
BX-2819 is a potent, selective Hsp90 inhibitor with KD of 16.4 nM for human Hsp90α, also is a potent B. burgdorferi high-temperature protein G (Bb HtpG) with KD of 12 nM. |
| PC-21200 |
NVP-HSP990
HSP90 inhibitor
|
NVP-HSP990 (HSP990) is a potent, selective, oral and brain-penetrant Hsp90 inhibitor with IC50 of 0.6, 0.8 and 8.5 nM for Hsp90α, Hsp90β and Grp94, respectively. |
| PC-20637 |
Foldlin
HSF-1 activator
|
Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator. |
| PC-20551 |
SOMCL-16-175
Hsp90α modulator
|
SOMCL-16-175 is a non-covalent, allosteric modulator targeting Hsp90α’s middle domain (Hsp90M) with binding Kd of 804 uM, inhibits breast cancer cell growth and proliferation. |
