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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-ML346
ML346

Chemical Structure : ML346

CAS No.: 100872-83-1

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ML346 (ML 346)

货号: PC-45512Not For Human Use, Lab Use Only.

ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ML346 is a small molecule activator of HSP70 with EC50 of 4.6 uM, induces HSF-1-dependent chaperone expression.
ML346 restores protein folding in conformational disease models, which are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.

物理化学性质&存储条件

分子量 272.2561
分子式 C14H12N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(4-methoxyphenyl)-2-propen-1-ylidene]-

参考文献

1. Calamini B, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].

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