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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-SNX-5422
SNX-5422

Chemical Structure : SNX-5422

CAS No.: 908115-27-5

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SNX-5422 (PF-04929113)

货号: PC-24852Not For Human Use, Lab Use Only.

SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

规格 价格 库存 数量
10 mg ￥780 In stock
25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SNX-5422 (PF-04929113) is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

物理化学性质&存储条件

分子量 521.54
分子式 C25H30F3N5O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

trans-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl 2-aminoacetate

参考文献

1. Lamoureux F, et al. Clin Cancer Res. 2011 Jul 15;17(14):4916.

2. Rajan A, et al. Clin Cancer Res. 2011 Nov 1;17(21):6831-9.

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