HSP110 inhibitor C7

Chemical Structure : HSP110 inhibitor C7

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货号: PC-26801Not For Human Use, Lab Use Only.

HSP110 inhibitor C7 is a potent, second generation heat shock protein 110 (HSP110) inhibitor, inhibits STAT3 activation, inhibits colorectal cancer cells proliferation.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HSP110 inhibitor C7 is a potent, second generation heat shock protein 110 (HSP110) inhibitor, inhibits STAT3 activation, inhibits colorectal cancer cells proliferation.
HSP110 inhibitor C7 effectively suppresses colorectal cell viability by inhibiting cell growth, with IC50 of 6.05 uM for SW480 cell line, 11.59 uM for HCT116 cells.
HSP110 inhibitor C7 inhibits IL-6-induced colorectal cancer cells migration, metastasis and EMT.
HSP110 inhibitor C7 (5 mg/kg, i.p.) daily for 30 days, inhibits colorectal tumor growth in HCT116 cell line xenografted nude mice model.

物理化学性质&存储条件

分子量	516.60
分子式	C29H32N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(3,4-Dimethoxyphenyl)hexahydropyrrolo [3,4-c]pyrrol-2(1H)-yl)-5-(3,4,5-trimethoxyphenyl)nicotinonitrile

参考文献

1. Abrey-Recalde MJ, et al. Cell Death Dis. 2026 May 19. doi: 10.1038/s41419-026-08826-7.

2. Xu L, et al. European Journal of Medicinal Chemistry Reports. 2023;7:100103.