VWK147 | HSP90 CTD dimerization inhibitor | Probechem Biochemicals

Chemical Structure : VWK147

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VWK147 (VWK-147)

货号: PC-25911Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

VWK147 is a specific second-generation small-molecule inhibitor targeting HSP90 CTD dimerization, induces cell death in cisplatin-sensitive and resistant UC cells (UCCs), and re-sensitizes resistant cells to cisplatin treatment.
VWK147, but not the N-terminal domain-targeting HSP90 inhibitor 17-AAG, in combination with mTOR inhibitors synergistically kills cisplatin-sensitive and -resistant UCCs.
VWK147 interacts with helices H4 and H5 of the CTD in a manner that would prevent CTD dimerization.
VWK147 destabilizes HSP90 client proteins in urothelial carcinoma cells but does not induce a heat shock response.
VWK147 induces LC3-II accumulation and inhibits autophagosome-lysosome fusion.
VWK147 induces conjugation of ATG8 proteins to single membranes (CASM).

物理化学性质&存储条件

分子量	674.72
分子式	C32H38N10O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-amino-N-(1-(sec-butyl)-2-((1-isobutyl-2-(methylcarbamoyl)-6-oxo-1,6-dihydropyrimidin-5-yl)carbamoyl)-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(4-methoxybenzyl)-6-oxo-1,6-dihydropyrimidine-2-carboxamide

参考文献

1. David C, et al. Cell Death Dis. 2025 Dec 23. doi: 10.1038/s41419-025-08330-4.

VWK147 (VWK-147)

生物&药学活性

物理化学性质&存储条件

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VWK147 (VWK-147)

生物&药学活性

物理化学性质&存储条件

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