DNAJC9 inhibitor A12

Chemical Structure : DNAJC9 inhibitor A12

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货号: PC-28681Not For Human Use, Lab Use Only.

DNAJC9 inhibitor A12 is a potent, specific, covalent inhibitor of DNAJC9 (Dnaj Heat Shock Protein Family (HSP40) Member C9) with SPR Kd of 12.8 uM, exerts anti-inflammatory activity.

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生物&药学活性

DNAJC9 inhibitor A12 is a potent, specific, covalent inhibitor of DNAJC9 (Dnaj Heat Shock Protein Family (HSP40) Member C9) with SPR Kd of 12.8 uM, exerts anti-inflammatory activity.
A12 exhibits significant inhibition of IL-6 and TNF-α secretion exerts anti-inflammatory effects in LPS-induced RAW264.7 cell model with IC50 of 0.87 uM and 0.67 uM respectively.
A12 specifically and covalently modifies the C243 residue of DNAJC9.
A12 promotes the intracellular aggregation of HSP70 under inflammatory conditions, significantly suppresses IκBα phosphorylation.
A12 induces significantly reducing the expression of TNF-α and IL-6 in both in vitro LPS-induced inflammation models and in vivo sepsis mice models of systemic acute inflammation.
DNAJC9 is a critical member of the HSP40/DNAJ family that modulates HSP70 activity.

物理化学性质&存储条件

分子量	492.57
分子式	C28H32N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-9-yl (E)-3-(4-(dimethylamino)but-2-enamido)propanoate

参考文献

1. Xingjun Li, et al. Acta Pharm Sin B. 2026 Oct;16(10):6892-6904.