| Cat. No. |
Product Name |
Information |
| PC-28722 |
YNW-1
EGFR inhibitor
|
YNW-1 is a bident, covalent EGFR inhibitor with IC50 of 15.82 nM, 18.97 nM and 62.45 nM for EGFR L858R Ba/F3, EGFR L858R/C775S Ba/F3, and EGFR L858R/C797S Ba/F3 cells respectvely, covalently targets both cysteines 775 and 797 simultaneously. |
| PC-28718 |
ZNL-0056
EGFR inhibitor
|
ZNL-0056 is a potent, bident, ATP-competitive inhibitor targets both the Cys797 and Cys775 in the ATP binding site of EGFR, demonstrates antiproliferative activity and downstream signaling in mutant EGFR Ba/F3 cells. |
| PC-28439 |
MKH066
HER2 inhibitor
|
MKH066 is a potent, selective HER2 tyrosine kinase inhibitor with IC50 of 2.5 nM against both EGFR and HER2. |
| PC-27975 |
BJ-2412
RYK inhibitor
|
BJ-2412 is a small molecule inhibitor of receptor-like tyrosine kinase RYK, inhibits RYK phosphorylation by disrupting its interaction with EGFR, shows anticancer activity against PDAC. |
| PC-26757 |
IAM1363
HER2 inhibitor
|
IAM1363 (IAM-1363, IAM-H1, ENT-H1) is a potent, irreversible and selective Type II inhibitor of HER2, prevents phosphorylation and activation of wild-type HER2 and variants with activating mutations in the tyrosine kinase domain. |
| PC-25435 |
AZ14289671
EGFR inhibitor
|
AZ14289671 is a potent, highly selective and blood-brain barrier penetrant irreversible inhibitor of EGFR exon 20 insertion (EGFRExon20Ins) mutations, inhibits EGFR phosphorylation across EGFRExon20Ins with IC50 of 17-41 nM, spares wild-type EGFR. |
| PC-25021 |
Sevabertinib
HER2 inhibitor
|
Sevabertinib (BAY 2927088) is a potent, selective, reversible inhibitor of mutant epidermal growth factor receptors 2 (HER2), including HER2 exon 20 insertions and HER2 point mutations. |
| PC-24971 |
Pebezertinib
EGFR inhibitor
|
Pebezertinib (BLU-451, LNG-451) is a potent, CNS-penetrant, wild-type EGFR sparing inhibitor of EGFR exon 20 insertion mutations, as well as atypical (G719C, G719S, L861Q) and common EGFR mutants. |
| PC-24741 |
HS-10375
EGFR C797S inhibitor
|
HS-10375 is a potent, selective EGFR C797S tyrosine kinase inhibitor, shows potent inhibitory activity against EGFR C797S mutations (Del19/T790M/C797S, L858R/T790M/C797S, Del19/C797S, and L858R/C797S), and common and/or T790M mutations (Del19, T790M, L858R/T790M, and Del19/T790M) with IC50 < 1.5 nM. |
| PC-24584 |
ELF3-MED23 interaction inhibitor YK1
ELF3-MED23 inhibitor
|
YK1 is a potent and selective PPI inhibitor for ELF3-MED23 with IC50 of 1.18 uM, 95 % inhibition at 10 uM, attenuates the HER2-mediated oncogenic signaling cascades. |
| PC-24169 |
Perzebertinib
HER2 inhibitor
|
Perzebertinib (Bizrolertinib, ZN-1041, ZN-A-1041) is a potent, selective BBB penetrable HER2 tyrosine kinase inhibitor. |
| PC-24132 |
Enozertinib
EGFR inhibitor
|
Enozertinib (ORIC-114) is a potent, brain penetrant, orally bioavailable, irreversible inhibitor of exon 20 insertions in EGFR and HER2. |
