Sevabertinib | HER2 inhibitor | Probechem Biochemicals

Chemical Structure : Sevabertinib

CAS No.: 2521285-05-0

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Sevabertinib (BAY 2927088, BAY2927088)

货号: PC-25021Not For Human Use, Lab Use Only.

Sevabertinib (BAY 2927088) is a potent, selective, reversible inhibitor of mutant epidermal growth factor receptors 2 (HER2), including HER2 exon 20 insertions and HER2 point mutations.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

Sevabertinib (BAY 2927088) is a potent, selective, reversible inhibitor of mutant epidermal growth factor receptors 2 (HER2), including HER2 exon 20 insertions and HER2 point mutations.
BAY 2927088 shows potent in vitro antiproliferative activity in tumor cell lines carrying HER2 mutations, and strongly blocks HER2 phosphorylation, thereby inhibiting HER2-mediated downstream MAPK signaling.

物理化学性质&存储条件

分子量	484.94
分子式	C24H25ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(3-((1,4-Dioxan-2-yl)methoxy)pyridin-4-yl)-3-((3-chloro-2-methoxyphenyl)amino)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

参考文献

1. Franziska Siegel, et al. Cancer Res (2025) 85 (8_Supplement_1): 5610.

2. Patent WO2020216781 A1.

Sevabertinib (BAY 2927088, BAY2927088)

生物&药学活性

物理化学性质&存储条件

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Sevabertinib (BAY 2927088, BAY2927088)

生物&药学活性

物理化学性质&存储条件

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