YNW-1 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : YNW-1

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YNW-1 (YNW1)

货号: PC-28722Not For Human Use, Lab Use Only.

YNW-1 is a bident, covalent EGFR inhibitor with IC50 of 15.82 nM, 18.97 nM and 62.45 nM for EGFR L858R Ba/F3, EGFR L858R/C775S Ba/F3, and EGFR L858R/C797S Ba/F3 cells respectvely, covalently targets both cysteines 775 and 797 simultaneously.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

YNW-1 is a bident, covalent EGFR inhibitor with IC50 of 15.82 nM, 18.97 nM and 62.45 nM for EGFR L858R Ba/F3, EGFR L858R/C775S Ba/F3, and EGFR L858R/C797S Ba/F3 cells respectvely, covalently targets both cysteines 775 and 797 simultaneously.
(50-100 nM) inhibits downstream signaling including p-EGFR/ERK and AKT.
YNW-1 has broad activity against EGFR mutants and delayed acquired mutations.

物理化学性质&存储条件

分子量	703.85
分子式	C39H45N9O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-(4-acryloyl-5-methyl-3,4-dihydroquinoxalin-1(2H)-yl)-8-(1-acryloylpiperidin-3-yl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

参考文献

1. Li Z, et al. ACS Cent Sci. 2026 Sep 29;12(10):1647-1658.

YNW-1 (YNW1)

生物&药学活性

物理化学性质&存储条件

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YNW-1 (YNW1)

生物&药学活性

物理化学性质&存储条件

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