| Cat. No. |
Product Name |
Information |
| PC-49349 |
Opevesostat
CYP11A1 inhibitor
|
Opevesostat (ODM-208, MK-5684) is a potent, selective, orally bioavailable CYP11A1 inhibitor, inhibits the biosynthesis of pregnenolone with IC50 of 15 nM in NCI-H295R cells. |
| PC-49296 |
BMS-351
CYP17A1 lyase inhibitor
|
BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM. |
| PC-49015 |
DLCI-1 dihydrochloride
CYP2A6 inhibitor
|
DLCI-1 dihydrochloride is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes. |
| PC-49014 |
DLCI-1
CYP2A6 inhibitor
|
DLCI-1 is a potent and selective CYP2A6 inhibitor with IC50 of 17 nM, 15-765-fold selectivity other major hepatic CYP enzymes. |
| PC-38446 |
Dafadine-A
DAF-9 inhibitor
|
Dafadine-A is a small molecule inhibitor of DAF-9 cytochrome P450, binds DAF-9 and specifically inhibits its enzymatic activity, promotes dauer formation and longevity of Caenorhabditis elegans. |
| PC-38385 |
Osilodrostat
CYP11 B2 inhibitor
|
Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase (CYP11B2) with IC50 of 2.5 and 0.7 nM, respectively. |
| PC-38384 |
Baxdrostat
Aldosterone synthase inhibitor
|
Baxdrostat (CIN-107, RO6836191) is a highly potent, selective, and competitive small molecule inhibitor of aldosterone synthase (CYP11 B2, steroid 18-hydroxylase) with Ki of 13 nM, >100-fold over 11β-hydroxylase. |
| PC-73413 |
Dexfadrostat
CYP11B2 inhibitor
|
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17). |
| PC-72852 |
VID400
CYP24A1 inhibitor
|
VID400 (NVP-VID400, SDZ285-428) is a potent, selective inhibitor of CYP24A1, also inhibits Trypanosoma cruzi (TC) CYP51. |
| PC-72686 |
DX308
CYP26 inhibitor
|
DX308 is a potent, selective dual CYP26A1/B1 inhibitor and retinoic acid metabolism blocking agent. |
| PC-72684 |
DX314
CYP26B1 inhibitor
|
DX314 is a potent, specific CYP26B1 inhibitor with IC50 of 108 nM, >15-fold selectivity over CYP26A1. |
| PC-72679 |
8-BOA
CYP4Z1 inhibitor
|
8-BOA (CYP4Z1-IN-2) is a selective and potent mechanism-based inactivator of breast cancer-associated CYP4Z1 with Ki of 2.2 uM. |
