Dual CYP19A1/CYP11B2 inhibitor X21 | CYP19A1/CYP11B2 inhibitor

Chemical Structure : Dual CYP19A1/CYP11B2 inhibitor X21

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Dual CYP19A1/CYP11B2 inhibitor X21 (X21)

货号: PC-21449Not For Human Use, Lab Use Only.

Dual CYP19A1/CYP11B2 inhibitor X21 is a potent and selective dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2) with IC50 of 2.3 nM and 29 nM, respectively.

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生物&药学活性

Dual CYP19A1/CYP11B2 inhibitor X21 is a potent and selective dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2) with IC50 of 2.3 nM and 29 nM, respectively.
X21 shows high selectivity with respect to 11β-hydroxylase (CYP11B1), as well as CYP3A4 and CYP1A2.
X21 shows potent antiproliferative activity against BC cell lines, particularly against the ER+ MCF-7 cells (IC50 of 0.26 μM at 72 h), and a remarkable pro-apoptotic effect.
X21 significantly inhibits mTOR phosphorylation, thereby negatively modulating the PI3K/Akt/mTOR axis.

物理化学性质&存储条件

分子量	213.24
分子式	C12H11N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((5-(Hydroxymethyl)-1H-imidazol-1-yl)methyl)benzonitrile

参考文献

1. Annachiara Tinivella, et al. ACS Pharmacology & Translational Science. 2023.

Dual CYP19A1/CYP11B2 inhibitor X21 (X21)

生物&药学活性

物理化学性质&存储条件

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Dual CYP19A1/CYP11B2 inhibitor X21 (X21)

生物&药学活性

物理化学性质&存储条件

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