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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Cytochrome P450 (CYPs)-Vicadrostat
Vicadrostat

Chemical Structure : Vicadrostat

CAS No.: 1868065-21-7

Vicadrostat (BI 690517, BI-690517)

货号: PC-24049Not For Human Use, Lab Use Only.

Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS, CYP11B2, steroid 18-hydroxylase)) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase.

物理化学性质&存储条件

分子量 317.73
分子式 C15H12ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzonitrile, 2-chloro-4-[(6R)-6,7-dihydro-6-(hydroxymethyl)-6-methyl-4-oxopyrano[3,4-d]imidazol-3(4H)-yl]-

参考文献

1. Katherine R Tuttle, et al. Lancet. 2024 Jan 27;403(10424):379-390.

2. Patent WO2016014736.

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